Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …

Epigenetic clocks are age predictors that use machine-learning models trained on DNA CpG
methylation values to predict chronological or biological age. Increases in predicted …

We performed a systematic analysis of blood DNA methylation profiles from 4483
participants from seven independent cohorts identifying differentially methylated positions …

Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …

DNA methylation differences in Alzheimer's disease (AD) have been reported. Here, we
conducted a meta-analysis of more than 1000 prefrontal cortex brain samples to prioritize …

The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …

Schizophrenia is a chronic, heterogeneous neurodevelopmental disorder that has complex
symptoms and uncertain etiology. Mounting evidence indicates the involvement of genetics …

Epigenetic modifications confer stable transcriptional patterns in the brain, and both normal
and abnormal brain function involve specialized brain regions. We examined DNA …

Background People with neurodegenerative disorders show diverse clinical syndromes,
genetic heterogeneity, and distinct brain pathological changes, but studies report overlap …