Glycosaminoglycans are natural heteropolysaccharides that are present in every
mammalian tissue. They are composed of repeating disaccharide units that consist of either …

How various macromolecules are exchanged between cells and how they gain entry into
recipient cells are fundamental questions in cell biology with important implications eg non …

Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

Endothelial cells (ECs) line all blood vessel walls and are exposed to the mechanical forces
of blood flow which modulate their function and play a role in vascular regulation …

The updated “Unifying Hypothesis of Alzheimer's disease”(AD) is described that links all the
observed neuropathology in AD brain (ie, plaques, tangles, and cerebrovascular amyloid …

Heparan sulfate proteoglycans are ubiquitously found at the cell surface and extracellular
matrix in all the animal species. This review will focus on the structural characteristics of the …

purpose. Corneal confocal microscopy is a reiterative, rapid, noninvasive in vivo clinical
examination technique capable of imaging corneal nerve fibers. Nerve fiber tortuosity may …

Heparanase is an endoglucuronidase that cleaves heparan sulfate chains of proteoglycans.
In many malignancies, high heparanase expression and activity correlate with an …

Fluid shear stresses are potent regulators of vascular homeostasis and powerful
determinants of vascular disease progression. The glycocalyx is a layer of …

Growth factor activity is localized within the natural extracellular matrix (ECM) by specific
noncovalent interactions with core ECM biomolecules, such as proteins and proteoglycans …