Skin barrier dysfunction, a defining feature of atopic dermatitis (AD), arises from multiple
interacting systems. In AD, skin inflammation is caused by host–environment interactions …

Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is driven by
both terminal keratinocyte differentiation defects and strong type 2 immune responses. In …

Mammals have evolved neurophysiologic reflexes, such as coughing and scratching, to
expel invading pathogens and noxious environmental stimuli. It is well established that …

Systemic type 2 inflammation encompassing T helper 2 (TH2)-type responses is emerging
as a unifying feature of both classically defined allergic diseases, such as asthma, and a …

Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

The development of atopic dermatitis (AD) in infancy and subsequent allergic rhinitis and
asthma in later childhood is known as the atopic march. This progressive atopy is dependent …

Lipids in the stratum corneum of atopic dermatitis (AD) patients differ substantially in
composition from healthy subjects. We hypothesized that hyperactivated type 2 immune …

For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …

Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is increasing in
prevalence around the world. Intensive research is ongoing to understand the mechanisms …

Type 2 immunity is critical for defense against cutaneous infections but also underlies the
development of allergic skin diseases. We report the identification in normal mouse dermis …