Blood rheology: key parameters, impact on blood flow, role in sickle cell disease and effects of exercise

E Nader, S Skinner, M Romana, R Fort… - Frontiers in …, 2019 - frontiersin.org
Blood viscosity is an important determinant of local flow characteristics, which exhibits shear
thinning behavior: it decreases exponentially with increasing shear rates. Both hematocrit …

Squeezing for life–properties of red blood cell deformability

R Huisjes, A Bogdanova, WW Van Solinge… - Frontiers in …, 2018 - frontiersin.org
Deformability is an essential feature of blood cells (RBCs) that enables them to travel
through even the smallest capillaries of the human body. Deformability is a function of (i) …

Increased blood viscosity and red blood cell aggregation in patients with COVID‐19

E Nader, C Nougier, C Boisson… - American journal of …, 2022 - Wiley Online Library
The aim of this study was to (1) analyze blood viscosity, red blood cell (RBC) deformability,
and aggregation in hospitalized patients with Coronavirus disease 19 (COVID‐19);(2) test …

Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels

J Albuisson, SE Murthy, M Bandell, B Coste… - Nature …, 2013 - nature.com
Dehydrated hereditary stomatocytosis is a genetic condition with defective red blood cell
membrane properties that causes an imbalance in intracellular cation concentrations …

Hereditary spherocytosis

S Perrotta, PG Gallagher, N Mohandas - The Lancet, 2008 - thelancet.com
Hereditary spherocytosis is a common inherited disorder that is characterised by anaemia,
jaundice, and splenomegaly. It is reported worldwide and is the most common inherited …

New guidelines for hemorheological laboratory techniques

OK Baskurt, M Boynard, GC Cokelet… - Clinical …, 2009 - journals.sagepub.com
This document, supported by both the International Society for Clinical Hemorheology and
the European Society for Clinical Hemorheology and Microcirculation, proposes new …

Biomechanics approaches to studying human diseases

GYH Lee, CT Lim - Trends in biotechnology, 2007 - cell.com
Nanobiomechanics has recently been identified as an emerging field that can potentially
make significant contributions in the study of human diseases. Research into biomechanics …

Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study

T Kanias, MC Lanteri, GP Page, Y Guo… - Blood …, 2017 - ashpublications.org
Genetic polymorphisms in blood donors may contribute to donor-specific differences in the
survival of red blood cells (RBCs) during cold storage and after transfusion. Genetic …

Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease

C Paszty, CM Brion, E Manci, HE Witkowska… - Science, 1997 - science.org
To create mice expressing exclusively human sickle hemoglobin (HbS), transgenic mice
expressing human α-, γ-, and βS-globin were generated and bred with knockout mice that …

Physical properties of blood and their relationship to clinical conditions

T Alexy, J Detterich, P Connes, K Toth, E Nader… - Frontiers in …, 2022 - frontiersin.org
It has been long known that blood health heavily influences optimal physiological function.
Abnormalities affecting the physical properties of blood have been implicated in the …