[HTML][HTML] Alzheimer's disease pathophysiology in the retina

BP Gaire, Y Koronyo, DT Fuchs, H Shi… - Progress in Retinal and …, 2024 - Elsevier
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …

Retinal imaging in Alzheimer's and neurodegenerative diseases

PJ Snyder, J Alber, C Alt, LJ Bain… - Alzheimer's & …, 2021 - Wiley Online Library
In the last 20 years, research focused on developing retinal imaging as a source of potential
biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased …

Retinal microvascular and neurodegenerative changes in Alzheimer's disease and mild cognitive impairment compared with control participants

SP Yoon, DS Grewal, AC Thompson, BW Polascik… - Ophthalmology …, 2019 - Elsevier
Purpose Evaluate and compare the retinal microvasculature in the superficial capillary
plexus (SCP) in Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively …

Retinal changes in Alzheimer's disease—integrated prospects of imaging, functional and molecular advances

VB Gupta, N Chitranshi, J den Haan, M Mirzaei… - Progress in retinal and …, 2021 - Elsevier
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder of the brain, clinically
characterised by cognitive deficits that gradually worsen over time. There is, at present, no …

Optical coherence tomography as retinal imaging biomarker of neuroinflammation/neurodegeneration in systemic disorders in adults and children

S Vujosevic, MM Parra, ME Hartnett, L O'Toole, A Nuzzi… - Eye, 2023 - nature.com
The retina and the optic nerve are considered extensions of the central nervous system
(CNS) and thus can serve as the window for evaluation of CNS disorders. Spectral domain …

Past, present and future role of retinal imaging in neurodegenerative disease

AH Kashani, S Asanad, JW Chan, MB Singer… - Progress in retinal and …, 2021 - Elsevier
Retinal imaging technology is rapidly advancing and can provide ever-increasing amounts
of information about the structure, function and molecular composition of retinal tissue in …

Retinal optical coherence tomography features associated with incident and prevalent Parkinson disease

SK Wagner, D Romero-Bascones, M Cortina-Borja… - Neurology, 2023 - AAN Enterprises
Background and Objectives Cadaveric studies have shown disease-related
neurodegeneration and other morphological abnormalities in the retina of individuals with …

Convolutional neural network to identify symptomatic Alzheimer's disease using multimodal retinal imaging

CE Wisely, D Wang, R Henao, DS Grewal… - British Journal of …, 2022 - bjo.bmj.com
Background/Aims To develop a convolutional neural network (CNN) to detect symptomatic
Alzheimer's disease (AD) using a combination of multimodal retinal images and patient data …

The association between vision impairment and incidence of dementia and cognitive impairment: a systematic review and meta-analysis

X Shang, Z Zhu, W Wang, J Ha, M He - Ophthalmology, 2021 - Elsevier
Topic The magnitude and direction of the association between vision impairment and
incident dementia and cognitive impairment in prospective cohort studies was estimated by …

Retinal biomarkers in Alzheimer's disease and mild cognitive impairment: A systematic review and meta-analysis

YJ Ge, W Xu, YN Ou, Y Qu, YH Ma, YY Huang… - Ageing Research …, 2021 - Elsevier
Background Retinal changes may reflect the pathophysiological processes in the central
nervous system and can be assessed by imaging modalities non-invasively. We aim to …