[HTML][HTML] Gene therapy in cardiology: is a cure for hypertrophic cardiomyopathy on the horizon?

ED Paratz, J Mundisugih, SJ Rowe, E Kizana… - Canadian Journal of …, 2024 - Elsevier
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy
worldwide, affecting approximately 1 in 500 individuals. Current therapeutic interventions …

Interdisciplinary psychosocial care for families with inherited cardiovascular diseases

C Caleshu, NA Kasparian, KS Edwards… - Trends in …, 2016 - Elsevier
Inherited cardiovascular diseases pose unique and complex psychosocial challenges for
families, including coming to terms with life-long cardiac disease, risk of sudden death, grief …

Association of race with disease expression and clinical outcomes among patients with hypertrophic cardiomyopathy

LA Eberly, SM Day, EA Ashley, DL Jacoby… - JAMA …, 2020 - jamanetwork.com
Importance Racial differences are recognized in multiple cardiovascular parameters,
including left ventricular hypertrophy and heart failure, which are 2 major manifestations of …

Patient experiences with hypertrophic cardiomyopathy: a conceptual model of symptoms and impacts on quality of life

E Zaiser, AJ Sehnert, A Duenas, S Saberi… - Journal of patient …, 2020 - Springer
Background Hypertrophic cardiomyopathy (HCM) is a primary myocardial disorder defined
by left ventricular hypertrophy that cannot be explained by another cardiac or systemic …

Are disease-specific patient-reported outcomes measures (PROMs) used in cardiogenetics? A systematic review

S van Pottelberghe, N Kupper, E Scheirlynck… - European journal of …, 2024 - nature.com
Patient-reported outcome measures (PROMs) are used to facilitate patient-centered care
(PCC). While studies in patients with cardiac conditions have revealed poorer health-related …

Factors influencing uptake of familial long QT syndrome genetic testing

C Burns, J McGaughran, A Davis… - American journal of …, 2016 - Wiley Online Library
Ongoing challenges of clinical assessment of long QT syndrome (LQTS) highlight the
importance of genetic testing in the diagnosis of asymptomatic at‐risk family members …

[HTML][HTML] Hypertrophic cardiomyopathy diagnosis and treatment in high-and low-income countries: a narrative review

EC Martinez, NY Ortiz-Garcia, DAH Hernandez… - Cureus, 2023 - ncbi.nlm.nih.gov
Hypertrophic cardiomyopathy (HCM) is a hereditary cardiac condition characterized by
unexplained left ventricular hypertrophy without a hemodynamic cause. This condition is …

Attitudes, knowledge and consequences of uncertain genetic findings in hypertrophic cardiomyopathy

C Burns, L Yeates, C Spinks, C Semsarian… - European Journal of …, 2017 - nature.com
With the surge of next-generation sequencing (NGS) technologies making almost all genetic
tests more affordable and available, cardiac genetic testing now routinely encompasses a …

Precisely where are we going? Charting the new terrain of precision prevention

KM Meagher, ML McGowan… - Annual Review of …, 2017 - annualreviews.org
In addition to genetic data, precision medicine research gathers information about three
factors that modulate gene expression: lifestyles, environments, and communities. The …

Psychological issues in managing families with inherited cardiovascular diseases

J Ingles - Cold Spring Harbor Perspectives in …, 2020 - perspectivesinmedicine.cshlp.org
The field of cardiovascular genetic counseling has evolved dramatically in recent years
largely to manage the unique psychological needs of the inherited cardiovascular disease …