The signal recognition particle (SRP) and its receptor compose a universally conserved and
essential cellular machinery that couples the synthesis of nascent proteins to their proper …

Accurate folding, assembly, localization, and maturation of newly synthesized proteins are
essential to all cells and require high fidelity in the protein biogenesis machineries that …

Accurate protein localization is crucial to generate and maintain organization in all cells.
Achieving accuracy is challenging, as the molecular signals that dictate a protein's cellular …

The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein conformational
change because it is a long lifetime, visible wavelength fluorophore that is small enough to …

Co-translational protein targeting by the Signal Recognition Particle (SRP) is an essential
cellular pathway that couples the synthesis of nascent proteins to their proper cellular …

Cotranslational protein targeting is a conserved process for membrane protein biogenesis.
In Escherichia coli, the essential ATPase SecA was found to cotranslationally target a subset …

Ribosomes synthesizing inner membrane proteins in Escherichia coli are targeted to the
membrane by the signal recognition particle (SRP) pathway. By rapid kinetic analysis we …

Protein targeting to the bacterial plasma membrane was generally thought to occur via two
major pathways: cotranslational targeting by signal recognition particle (SRP) and …

Bioconjugating protein to nonbiological surfaces is an essential component of many
promising biotechnologies impacting diverse applications such as medical diagnostics …

Photodynamic therapy (PDT) is now in clinical practice in many European and American
countries as a minimally invasive therapeutic technique to treat oncologic malignancies and …