Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

Cardiovascular disease (CVD) remains the leading cause of mortality in women, yet many
people perceive breast cancer to be the number one threat to women's health. CVD and …

The effects of autonomic innervation of tumors on tumor growth remain unclear. Here we
developed a series of genetic techniques to manipulate autonomic innervation in a tumor …

Renin-angiotensin system (RAS) inhibitors (RASi)—widely prescribed for the treatment of
cardiovascular diseases—have considerable potential in oncology. The RAS plays a crucial …

Neurotransmitters are conventionally viewed as nerve-secreted substances that mediate the
stimulatory or inhibitory neuronal functions through binding to their respective receptors. In …

Cancer diagnostics and therapies have improved steadily over the last few decades,
markedly increasing life expectancy for patients at all ages. However, conventional and …

Chronic stress results in disturbances of body hormones through the neuroendocrine
system. Cancer patients often experience recurrent anxiety and restlessness during disease …

The use of repurposing drugs that may have neoplastic and anticancer effects increases the
efficiency and decrease resistance to chemotherapy drugs through a biochemical and …

Purpose The autonomic nervous system, consisting of sympathetic and
parasympathetic/vagal nerves, is known to control the functions of any organ, maintaining …

Abstract β-Blockers have been reported to exhibit potential anticancer effects in cancer cell
lines and animal models. However, clinical studies have yielded inconsistent results …