The direct method (HA (soln)⇌ A (soln)–+ H (soln)+) for calculating p K a of monoprotic acids
is as efficient as thermodynamic cycles. A selective adjustment of proton free energy in …

The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME)
of drugs, thus knowing this value is critical in drug development. In this review, pKa values …

Commonly used indicators for acid‐base titrations are synthetic, and this work was focused
to identify the eco‐friendly natural indicators and to determine their pKa values. The …

It is of great importance to develop new strategies to combat antibiotic resistance. Our lab
has discovered halogenated phenazine (HP) analogues that are highly active against …

Introduction: Ruthenium (II) complexes have emerged recently as candidates for anti-cancer
therapy, where activity is related to lipohilicity, cellular localization, and specific interactions …

Pathogenic bacteria have devastating impacts on human health as a result of acquired
antibiotic resistance and innate tolerance. Every class of our current antibiotic arsenal was …

COMPASS is a novel tool for predicting the in vivo similarity of immediate-release oral
dosage forms. It bridges the gap between straightforward but purely mathematical f2 factor …

We report a modified carbocyanine-based asymmetric fluorescent dye, suitable for the azide-
alkyne cycloaddition reaction, that possesses promising photochemical properties (Φ fl= 0 …

Purpose: Hydrazones are a class of azomethines with a wide spectrum of pharmacological
properties that are influenced by the pH of the media. The purpose of this study was to …

ABSTRACT UV-spectrophotometric determination of dissociation constant (pKa) is used
routinely in various research fields. This review highlights the structural attributes of organic …