Physiological and pathological roles of protein kinase A in the heart
Protein kinase A (PKA) is a central regulator of cardiac performance and morphology.
Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress …
Myocardial PKA activation is induced by a variety of hormones, neurotransmitters, and stress …
TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure–function relationships
JJ Sheng, JP Jin - Gene, 2016 - Elsevier
Troponin I (TnI) is the inhibitory subunit of the troponin complex in the sarcomeric thin
filament of striated muscle and plays a central role in the calcium regulation of contraction …
filament of striated muscle and plays a central role in the calcium regulation of contraction …
Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities
Unravelling the dynamic molecular interplay behind complex physiological processes such
as neuronal plasticity requires the ability to both detect minute changes in biochemical …
as neuronal plasticity requires the ability to both detect minute changes in biochemical …
Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism
MY Jeong, YH Lin, SA Wennersten… - Science translational …, 2018 - science.org
There are no approved drugs for the treatment of heart failure with preserved ejection
fraction (HFpEF), which is characterized by left ventricular (LV) diastolic dysfunction. We …
fraction (HFpEF), which is characterized by left ventricular (LV) diastolic dysfunction. We …
Pharmacological targeting of AKAP-directed compartmentalized cAMP signalling
A Dema, E Perets, MS Schulz, VA Deák, E Klussmann - Cellular signalling, 2015 - Elsevier
The second messenger cyclic adenosine monophosphate (cAMP) can bind and activate
protein kinase A (PKA). The cAMP/PKA system is ubiquitous and involved in a wide array of …
protein kinase A (PKA). The cAMP/PKA system is ubiquitous and involved in a wide array of …
Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation
Tropomyosin, controlled by troponin-linked Ca 2+-binding, regulates muscle contraction by
a macromolecular scale steric-mechanism that governs myosin-crossbridge–actin …
a macromolecular scale steric-mechanism that governs myosin-crossbridge–actin …
Clinical pharmacology of cardiac cyclic AMP in human heart failure: too much or too little?
A Lymperopoulos - Expert Review of Clinical Pharmacology, 2023 - Taylor & Francis
ABSTRACT Introduction Cyclic 3', 5'-adenosine monophosphate (cAMP) is a major signaling
hub in cardiac physiology. Although cAMP signaling has been extensively studied in cardiac …
hub in cardiac physiology. Although cAMP signaling has been extensively studied in cardiac …
Cardiac troponin structure-function and the influence of hypertrophic cardiomyopathy associated mutations on modulation of contractility
Cardiac troponin (cTn) acts as a pivotal regulator of muscle contraction and relaxation and is
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …
Umbrella sampling simulations measure switch peptide binding and hydrophobic patch opening free energies in cardiac troponin
AM Cool, S Lindert - Journal of chemical information and …, 2022 - ACS Publications
The cardiac troponin (cTn) complex is an important regulatory protein in heart contraction.
Upon binding of Ca2+, cTn undergoes a conformational shift that allows the troponin I switch …
Upon binding of Ca2+, cTn undergoes a conformational shift that allows the troponin I switch …
Transcriptome and functional profile of cardiac myocytes is influenced by biological sex
CL Trexler, AT Odell, MY Jeong… - Circulation …, 2017 - Am Heart Assoc
Background—Although cardiovascular disease is the primary killer of women in the United
States, women and female animals have traditionally been omitted from research studies. In …
States, women and female animals have traditionally been omitted from research studies. In …