Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

The orchestrated organization of epigenetic factors that control chromatin dynamism,
including DNA methylation, histone marks, non-coding RNAs (ncRNAs) and chromatin …

We used trio-based whole-exome sequencing to analyze two families affected by Weaver
syndrome, including one of the original families reported in 1974. Filtering of rare variants in …

Epigenetic control of gene expression is critical for normal fetal development. However,
chromatin-related mechanisms that activate bone-specific programs during osteogenesis …

Fine control of Wnt signaling is essential for various cellular and developmental decision-
making processes. However, deregulation of Wnt signaling leads to pathological …

Mesenchymal stem cells (MSCs) have putative roles in maintaining adult tissue health, and
the functional decline of MSCs has emerged as a crucial pathophysiological driver of …

The emergence of craniofacial skeletal elements, and of the jaw in particular, was a crucial
step in the evolution of higher vertebrates. Most facial bones and cartilage are generated …

Upon WNT/β-catenin pathway activation, stabilized β-catenin travels to the nucleus where it
associates with the TCF/LEF transcription factors, constitutively bound to genomic Wnt …

Epigenetic mechanisms control skeletal development and osteoblast differentiation.
Pharmacological inhibition of the histone 3 Lys-27 (H3K27) methyltransferase enhancer of …

Bone-stimulatory therapeutics include bone morphogenetic proteins (eg BMP2), parathyroid
hormone, and antibody-based suppression of WNT antagonists. Inhibition of the epigenetic …