Circuit organization of the rodent medial prefrontal cortex
PG Anastasiades, AG Carter - Trends in neurosciences, 2021 - cell.com
The prefrontal cortex (PFC) orchestrates higher brain function and becomes disrupted in
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …
many mental health disorders. The rodent medial PFC (mPFC) possesses an enormous …
Prefrontal cortex circuits in depression and anxiety: contribution of discrete neuronal populations and target regions
Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
ketamine as a rapid-acting antidepressant and the development and refinement of tools …
Neuronal defects in a human cellular model of 22q11. 2 deletion syndrome
Abstract 22q11. 2 deletion syndrome (22q11DS) is a highly penetrant and common genetic
cause of neuropsychiatric disease. Here we generated induced pluripotent stem cells from …
cause of neuropsychiatric disease. Here we generated induced pluripotent stem cells from …
Corticostriatal connectivity and its role in disease
GMG Shepherd - Nature Reviews Neuroscience, 2013 - nature.com
Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …
involved in motivated behaviour. These axonal projections are formed by two distinct …
[HTML][HTML] Dopaminergic modulation of synaptic transmission in cortex and striatum
NX Tritsch, BL Sabatini - Neuron, 2012 - cell.com
Among the many neuromodulators used by the mammalian brain to regulate circuit function
and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful …
and plasticity, dopamine (DA) stands out as one of the most behaviorally powerful …
[HTML][HTML] The autism-associated gene Scn2a contributes to dendritic excitability and synaptic function in the prefrontal cortex
Autism spectrum disorder (ASD) is strongly associated with de novo gene mutations. One of
the most commonly affected genes is SCN2A. ASD-associated SCN2A mutations impair the …
the most commonly affected genes is SCN2A. ASD-associated SCN2A mutations impair the …
[HTML][HTML] Neuromodulatory systems and their interactions: a review of models, theories, and experiments
MC Avery, JL Krichmar - Frontiers in neural circuits, 2017 - frontiersin.org
Neuromodulatory systems, including the noradrenergic, serotonergic, dopaminergic, and
cholinergic systems, track environmental signals, such as risks, rewards, novelty, effort, and …
cholinergic systems, track environmental signals, such as risks, rewards, novelty, effort, and …
Dissecting the diversity of midbrain dopamine neurons
J Roeper - Trends in neurosciences, 2013 - cell.com
Midbrain dopamine (DA) neurons are essential for controlling key functions of the brain,
such as voluntary movement, reward processing, and working memory. The largest …
such as voluntary movement, reward processing, and working memory. The largest …
[HTML][HTML] Prefrontal dopamine and behavioral flexibility: shifting from an “inverted-U” toward a family of functions
SB Floresco - Frontiers in neuroscience, 2013 - frontiersin.org
Studies on prefrontal cortex (PFC) dopamine (DA) function have revealed its essential role
in mediating a variety of cognitive and executive functions. A general principle that has …
in mediating a variety of cognitive and executive functions. A general principle that has …
[HTML][HTML] Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant effects
Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the
therapeutic response produced by novel rapid-acting antidepressants such as ketamine are …
therapeutic response produced by novel rapid-acting antidepressants such as ketamine are …