Cerebral ischemic stroke is characterized by acute ischemia in a certain part of the brain,
which leads to brain cells necrosis, apoptosis, ferroptosis, pyroptosis, etc. At present, there …

Despite recent advances in the management of chronic kidney disease (CKD), morbidity
and mortality rates in these patients remain high. While pressure-mediated injury is a well …

Unilateral ureteral obstruction (UUO) is an experimental rodent model that mimics renal
fibrosis associated with obstructive nephropathy in an accelerated manner. After UUO, the …

Abnormal cellular accumulation of the dicarbonyl metabolite MG (methylglyoxal) occurs on
exposure to high glucose concentrations, inflammation, cell aging and senescence. It is …

Alport syndrome affects up to 60,000 people in the United States. The proposed
reclassification of thin basement membrane nephropathy and some cases of focal …

Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted
to become by 2040 the fifth global cause of death. CKD is characterized by increased …

The nuclear factor erythroid 2-related factor 2 (Nrf2) protects the cell against oxidative
damage. The Nrf2 system comprises a complex network that functions to ensure adequate …

From an evolutionary point of view, vitamin D and melatonin appeared very early and share
functions related to defense mechanisms. In the current clinical setting, vitamin D is …

Redox is a constant phenomenon in organisms. From the signaling pathway transduction to
the oxidative stress during the inflammation and disease process, all are related to reduction …

Exacerbated oxidative stress and inflammation may induce three types of programmed cell
death, autophagy, apoptosis and pyroptosis in unilateral ureteral obstruction (UUO) kidney …