Primaquine was firstly synthesized in 1946 in the USA, and is the most representative
member of the anti-malarial 8-aminoquinolines. Six decades have passed and primaquine …

The technical genesis and practice of 8-aminoquinoline therapy of latent malaria offer
singular scientific, clinical, and public health insights. The 8-aminoquinolines brought …

Background The efficacy of the 8-aminoquinoline (8AQ) drug primaquine (PQ) has been
historically linked to CYP-mediated metabolism. Although to date no clear evidence exists in …

Objective Knowledge about the metabolism of anti-parasitic drugs (APDs) will be helpful in
ongoing efforts to optimise dosage recommendations in clinical practise. This study was …

A great deal has been learned about the behaviour of monoamine oxidase in the 75 years
since it was first discovered, but there is still a great deal left to understand. This review …

Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

Emerging antimalarial drug resistance may undermine current efforts to control and
eliminate Plasmodium vivax, the most geographically widespread yet neglected human …

The prevention and management of malaria is primarily based on the use of drugs. Clinical
trials have however revealed that between individuals there is large variability in the …

Abstract Background The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only
approved drug effective against the persistent liver stage of the hypnozoite forming strains …

Malaria and tuberculosis (TB) are two major global diseases mostly affecting the developing
countries. Their treatment is often complex because of the drugs used, multidrug resistance …