In the vertebrate central nervous system, multipotential cells have been identified in vitro and
in vivo. Defined mitogens cause the proliferation of multipotential cells in vitro, the …

The molecular underpinnings of cerebellar development are being established through the
identification of naturally occurring mutated genes and the knockout of other genes. Sets of …

We describe a method termed MADM (mosaic analysis with double markers) in mice that
allows simultaneous labeling and gene knockout in clones of somatic cells or isolated single …

In the neurological mutant mouse reeler, the histological organization of the neocortex
develops abnormally and essentially results in an inversion of the relative positions of the …

Recent advances in molecular biology have drastically changed our vision on the
development of the nervous system, the cerebellum in particular. After a classical descriptive …

Post-mitotic neurons generated at the rhombic lip undertake long distance migration to
widely dispersed destinations, giving rise to cerebellar granule cells and the precerebellar …

We have used a combination of quail-chick fate-mapping techniques and dye labelling to
investigate the development of the avian cerebellum. Using Hoxa2 as a guide for the …

At birth or after hatching from the egg, vertebrate brains still contain neural stem cells which
reside in specialized niches. In some cases, these stem cells are deployed for further …

After their final mitosis, cerebellar granule cells remain in the external granular layer (EGL)
for 20–48 hr before initiating their radial migration across the molecular layer (ML), but the …

The specification of diverse classes of neurons is critical to the development of the
cerebellar cortex. Here, we describe the purification of early embryonic precursors of …