Tailor-made amino acids in the design of small-molecule blockbuster drugs

J Han, H Konno, T Sato, VA Soloshonok… - European Journal of …, 2021 - Elsevier
The role of amino acids (AAs) in modern health industry is well-appreciated. Residues of
individual AAs, or their chemical modifications, such as diamines and amino alcohols, are …

[HTML][HTML] Twenty-first century antiepileptic drugs. An overview of their targets and synthetic approaches

JD Sánchez, J Gómez-Carpintero, JF González… - European Journal of …, 2024 - Elsevier
The therapeutic use of the traditional drugs against epilepsy has been hindered by their
toxicity and low selectivity. These limitations have stimulated the design and development of …

Development of Scalable Conditions for the Ugi ReactionApplication to the Synthesis of (R)-Lacosamide

H Wehlan, J Oehme, A Schäfer… - … Process Research & …, 2015 - ACS Publications
The Ugi reaction is applied for the preparation of (R)-lacosamide, an important drug for the
treatment of epilepsy. To this end, key issues associated with the Ugi reaction, such as a …

A Short Review of Synthetic Routes for the Antiepileptic Drug (R)-Lacosamide

EK Aratikatla, AK Bhattacharya - Organic Process Research & …, 2019 - ACS Publications
The disease epilepsy affects people of all ages and is due to a chronic neurological disorder
in the brain. According to a report by the World Health Organization, epilepsy is one of the …

Chiral pool approach for the synthesis of functionalized amino acids: synthesis of antiepileptic drug (R)-lacosamide

EK Aratikatla, AK Bhattacharya - Tetrahedron Letters, 2015 - Elsevier
Chiral pool approach for the synthesis of functionalized amino acids: synthesis of antiepileptic
drug (R)-lacosamide - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals …

Total synthesis of haliclamide

S Gahalawat, SK Pandey - Organic & Biomolecular Chemistry, 2016 - pubs.rsc.org
A stereoselective approach for the synthesis of haliclamide 1, a marine natural product, has
been developed. The notable features of our synthesis include MacMillan cross aldol …

Organocatalytic Asymmetric Tandem α‐Aminooxylation–Henry Reactions for the Synthesis of 1,2‐Diols: Total Synthesis of (–)‐lthreo‐Sphinganine

Y Garg, R Kaur, S Kumar Pandey - European Journal of …, 2017 - Wiley Online Library
A new and rapid asymmetric synthesis of anti‐and syn‐β, γ‐dihydroxynitroalkanes through
an organocatalytic tandem α‐aminooxylation–Henry reaction is described. The target diol …

Organocatalyzed Protecting-Group-Free Total Synthesis of (S,S)- and (S,R)-Reboxetine, an Antidepressant Drug

A Sharma, SK Pandey - The Journal of Organic Chemistry, 2022 - ACS Publications
An efficient, simple, and concise organocatalyzed protecting-group-free synthetic approach
to the stereoisomers of the antidepressant drug reboxetine and its implementation toward …

A short total synthesis of the antimalarial flindersial alkaloids

R Kaur, Y Garg, SK Pandey - ChemistrySelect, 2016 - Wiley Online Library
A short, efficient and novel approach for the syntheses of bis‐indole alkaloids flinderoles A−
C, and desmethylflinderole C, is being described. The synthesis utilizes the optimized …

Enantioselective total synthesis of cis-(+)-and trans-(+)-disparlure

Y Garg, AK Tiwari, SK Pandey - Tetrahedron Letters, 2017 - Elsevier
An expedient enantioselective synthetic approach for the gypsy moth sex-attractant
pheromone cis-(+)-1 and trans-(+)-disparlure 2 is described employing the optimized …