Food, a vital component of our daily life, is fundamental to our health and well-being, and the
knowledge and practices relating to food have been passed down from countless …

The human trophic level (HTL) during the Pleistocene and its degree of variability serve,
explicitly or tacitly, as the basis of many explanations for human evolution, behavior, and …

The global obesity epidemic is the subject of an immense, diversely specialized research
effort. An evolutionary analysis reveals connections among disparate findings, starting with …

Rates of type 2 diabetes (T2D) and hypertension are increasing rapidly in urbanizing sub-
Saharan Africa (SSA). While lifestyle factors drive the increases in T2D and hypertension …

We have investigated the evidence for positive selection in samples of African, European,
and East Asian ancestry at 65 loci associated with susceptibility to type 2 diabetes (T2D) …

Demographic changes are known to leave footprints on genetic polymorphism. Together
with the increased availability of large polymorphism data sets, coalescent-based methods …

The" thrifty gene hypothesis" suggests genetic susceptibility to obesity arises because of
positive selection for alleles that favored fat deposition and survival during famines. We used …

Over the past 8 years, the genetics of complex traits have benefited from an unprecedented
advancement in the identification of common variant loci for diseases such as type 2 …

Common variants in the UMOD gene encoding uromodulin, associated with risk of
hypertension and CKD in the general population, increase UMOD expression and urinary …

Background We have previously shown that a Palaeolithic diet consisting of the typical food
groups that our ancestors ate during the Palaeolithic era, improves cardiovascular disease …