Tumors can escape immunity through multiple mechanisms, one of which is by enforcing a
state of unresponsiveness of the tumor vasculature to inflammatory cytokines. This results in …

Tregs imprint an early immunotolerant tumor environment that prevents effective antitumor
immune responses. Using transcriptomics of tumor tissues, we identified early upregulation …

A successful pregnancy requires the maternal immune system to tolerate an allogeneic
fetus. The incidence of preeclampsia and other complications related to impaired fetal …

The placenta relies on phenotypes that are characteristic of cancer to successfully implant
the embryo in the uterus during early pregnancy. Notably, it has to invade its host tissues …

Background Embryo implantation into the uterus is a crucial step for human reproduction. A
hypothesis has been proposed that the molecular circuit invented by trophoblasts for …

Introduction Autoimmune and autoinflammatory diseases (AIDs) represent a socioeconomic
burden as the second cause of chronic illness in Western countries. In this context, the …

Toxicity studies in pregnant animals are not always necessary for assessing the human risk
of developmental toxicity of biopharmaceuticals. The growing experience and information on …

Background Identifying differentially expressed genes between experimental conditions is
still the gold-standard approach to interpret transcriptomic profiles. Alternative approaches …

Background Due to rapid research progress in reproductive biology and reproductive
clinical endocrinology, many human infertility treatments are close to potential …

Ce chapitre va permettre d'illustrer le concept de «traces» dans le corps humain, générées
par le systeme immunitaire et transmises entre les générations. Conformément ala …