Enzymes control chemical reactions that are key to life processes, and allow them to take
place on the time scale needed for synchronization between the relevant reaction cycles. In …

Enzymes are dynamic entities, and their dynamic properties are clearly linked to their
biological function. It follows that dynamics ought to play an essential role in enzyme …

One of the critical variables that determine the rate of any reaction is temperature. For
biological systems, the effects of temperature are convoluted with myriad (and often …

Quantum mechanical tunneling of atoms is increasingly found to play an important role in
many chemical transformations. Experimentally, atom tunneling can be indirectly detected …

We review the adaptations of enzyme activity to different temperatures. Psychrophilic (cold-
adapted) enzymes show significantly different activation parameters (lower activation …

Efficient O2 reduction reaction (ORR) for selective H2O generation enables advanced fuel
cell technology. Nonprecious metal catalysts are viable and attractive alternatives to state-of …

Understanding allostery in enzymes and tools to identify it offer promising alternative
strategies to inhibitor development. Through a combination of equilibrium and …

Conspectus Biological activities of enzymes, including regulation or coordination of
mechanistic stages preceding or following the chemical step, may depend upon kinetic or …

The functional cycle of many proteins involves large-scale motions of domains and subunits.
The relation between conformational dynamics and the chemical steps of enzymes remains …

Heat capacity changes are emerging as essential for explaining the temperature
dependence of enzyme-catalysed reaction rates. This has important implications for enzyme …