Cell membranes contain a large variety of lipid types and are crowded with proteins,
endowing them with the plasticity needed to fulfill their key roles in cell functioning. The …

A celebrated and controversial hypothesis suggests that some biological systems—parts,
aspects, or groups of them—may extract important functional benefits from operating at the …

Cell surface transmembrane receptors often form nanometer-to micrometer-scale clusters to
initiate signal transduction in response to environmental cues. Extracellular ligand …

Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Since its initial formalization nearly 20 years ago, the concept of lipid rafts has generated a
tremendous amount of attention and interest and nearly as much controversy. The …

The fluid mosaic model of Singer and Nicolson (1972) is a commonly used representation of
the cell membrane structure and dynamics. However a number of features, the result of four …

Lipid membranes can spontaneously organize their components into domains of different
sizes and properties. The organization of membrane lipids into nanodomains might …

Diverse cellular signaling events, including B cell receptor (BCR) activation, are
hypothesized to be facilitated by domains enriched in specific plasma membrane lipids and …

The recent rapid accumulation of knowledge on the dynamics and structure of the plasma
membrane has prompted major modifications of the textbook fluid-mosaic model. However …