Selective p300 degradation via peptide PROTAC: a new therapeutic strategy for advanced prostate cancers

LY Wang - EBioMedicine, 2024 - thelancet.com
Ling-Yu Wang a, b, c,∗ aDepartment of Biochemistry and Molecular Biology, Chang Gung
University, Taoyuan 33302, Taiwan bDivision of Hematology-Oncology, Chang Gung …

[HTML][HTML] Paralogue-selective degradation of the lysine acetyltransferase EP300

X Chen, MKC Crawford, Y Xiong, AB Shaik, KF Suazo… - bioRxiv, 2024 - ncbi.nlm.nih.gov
The transcriptional coactivators EP300 and CREBBP are critical regulators of gene
expression that share high sequence identity but exhibit non-redundant functions in basal …