Poly (ADP-ribosyl) ation, attaching the ADP-ribose polymer chain to the receptor protein, is a
unique posttranslational modification. Poly (ADP-ribose) polymerase-1 (PARP-1) is a well …

Acute lung injury (ALI) and its more severe form acute respiratory distress syndrome (ARDS)
are life-threatening diseases that are characterized by acute onset, pulmonary inflammation …

Background Poly (ADP-ribose) polymerase (PARP) inhibitors (eg, olaparib) are effective
against BRCA-mutated cancers at/near maximum tolerated doses by trapping PARP-1 on …

Background Despite many studies on endoplasmic reticulum (ER) stress in patients with
various inflammatory diseases, there is scarce information on ER stress in patients with …

Abstract Poly (ADP-ribosyl) ation (PARylation) is mainly catalysed by poly-ADP-ribose
polymerase 1 (PARP1), whose role in gene transcription modulation has been well …

Background Nicotinamide (NAM) is a form of vitamin B3 that, when administered at near-
gram doses, has been shown or suggested to be therapeutically effective against many …

Poly (ADP-ribose) polymerase-1 (PARP-1) and PARP-2 are enzymes which post-
translationally modify proteins through poly (ADP-ribosyl) ation (PARylation)—the transfer of …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell
cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced …

We have previously shown that PARP-1 inhibition provides protection against lung
inflammation in the context of asthma and acute lung injury. Olaparib is a potent new …

Asthma, acute lung injury (ALI), and chronic obstructive pulmonary disease (COPD) are lung
inflammatory disorders with a common outcome, that is, difficulty in breathing …