The Arp2/3 complex orchestrates the formation of branched actin networks at the interface
between the cytoplasm and membranes. Although it is widely appreciated that these …

A review of our current knowledge of B cell antigen uptake mechanisms, the relevance of
these processes to pathology, and outstanding questions in the field. Specific antigens …

Clathrin-mediated endocytosis (CME) requires energy input from actin polymerization in
mechanically challenging conditions. The roles of actin in CME are poorly understood due to …

B-cell activation and immune synapse (IS) formation with membrane-bound antigens are
actin-dependent processes that scale positively with the strength of antigen-induced signals …

Differentiation of B cells into antibody-secreting cells (ASCs) is a key process to generate
protective humoral immunity. A detailed understanding of the cues controlling ASC …

Fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG) are
debilitating diseases that share causal mutations in ACVR1, a TGF‐β family type I receptor …

B cell receptor (BCR)-mediated antigen-specific recognition activates B lymphocytes and
drives the humoral immune response. This enables the generation of antibody-producing …

B cell adapter for PI 3-kinase (BCAP) is an adaptor molecule associated with signaling
through multiple immune receptors, including the B cell receptor (BCR). However, B cell …

Subcapsular sinus macrophages (SSMs) play a key role in immune defense by forming
immunological barriers that control the transport of antigens from lymph into lymph node …

Mechanosensing, or how cells sense and respond to the physical environment, is crucial for
many aspects of biological function, ranging from cell movement during development to …