Significant progress has recently been made in our understanding of animal regenerative
biology, spurred on by the use of a wider range of model organisms and an increasing …

The regeneration of complex structures in adult salamanders depends on mechanisms that
offer pointers for regenerative medicine. These include the plasticity of differentiated cells …

Humans and other mammals are limited in their natural abilities to regenerate lost body
parts. By contrast, many salamanders are highly regenerative and can spontaneously …

Molecular markers have become a fundamental piece of modern biology's toolkit. In the last
decade, new genomic resources from model organisms and advances in DNA sequencing …

Understanding how the limb blastema is established after the initial wound healing
response is an important aspect of regeneration research. Here we performed parallel …

Modern analytical methods for population genetics and phylogenetics are expected to
provide more accurate results when data from multiple genome‐wide loci are analysed. We …

Background Microarray analysis and 454 cDNA sequencing were used to investigate a
centuries-old problem in regenerative biology: the basis of nerve-dependent limb …

Axolotls (urodele amphibians) have the unique ability, among vertebrates, to perfectly
regenerate many parts of their body including limbs, tail, jaw and spinal cord following injury …

Background Following amputation, urodele salamander limbs reprogram somatic cells to
form a blastema that self-organizes into the missing limb parts to restore the structure and …

The experimental study of amphibian limb regeneration spans most of the 20th century and
the first decade of the 21st century. We first review the major questions investigated over this …