The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
TR Suk, MWC Rousseaux - Molecular neurodegeneration, 2020 - Springer
Since its discovery as a primary component in cytoplasmic aggregates in post-mortem tissue
of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP …
of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP …
Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis
A Prasad, V Bharathi, V Sivalingam… - Frontiers in molecular …, 2019 - frontiersin.org
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD
The cytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43)
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …
is a common histopathological hallmark of the amyotrophic lateral sclerosis and …
The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity
During eukaryotic evolution, ribosomes have considerably increased in size, forming a
surface-exposed ribosomal RNA (rRNA) shell of unknown function, which may create an …
surface-exposed ribosomal RNA (rRNA) shell of unknown function, which may create an …
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from
many diverse genetic causes. Although therapeutics specifically targeting known causal …
many diverse genetic causes. Although therapeutics specifically targeting known causal …
Physiological functions and pathobiology of TDP‐43 and FUS/TLS proteins
The multiple roles played by RNA binding proteins in neurodegeneration have become
apparent following the discovery of TAR DNA binding protein 43 kDa (TDP‐43) and fused in …
apparent following the discovery of TAR DNA binding protein 43 kDa (TDP‐43) and fused in …
Stability properties of neuronal microtubules
Neurons are terminally differentiated cells that use their microtubule arrays not for cell
division but rather as architectural elements required for the elaboration of elongated axons …
division but rather as architectural elements required for the elaboration of elongated axons …
[HTML][HTML] RNA dysregulation in amyotrophic lateral sclerosis
Z Butti, SA Patten - Frontiers in genetics, 2019 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease
and is characterized by the degeneration of upper and lower motor neurons. It has become …
and is characterized by the degeneration of upper and lower motor neurons. It has become …
[HTML][HTML] Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?
KJ De Vos, M Hafezparast - Neurobiology of disease, 2017 - Elsevier
Intracellular trafficking of cargoes is an essential process to maintain the structure and
function of all mammalian cell types, but especially of neurons because of their extreme …
function of all mammalian cell types, but especially of neurons because of their extreme …
[HTML][HTML] Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum
Y Baradaran-Heravi, C Van Broeckhoven… - Neurobiology of …, 2020 - Elsevier
Stress granules (SGs) are dynamic membraneless compartments composed out of RNA-
binding proteins (RBPs) and RNA molecules that assemble temporarily to allow the cell to …
binding proteins (RBPs) and RNA molecules that assemble temporarily to allow the cell to …