Water solubility and structural stability are key merits for proteins defined by the primary
sequence and 3D-conformation. Their manipulation represents important aspects of the …

Proteins are molecular machines whose function depends on their ability to achieve
complex folds with precisely defined structural and dynamic properties. The rational design …

Protein design is a powerful tool for elucidating mechanisms of function and engineering
new therapeutics and nanotechnologies. Although soluble protein design has advanced …

Interactions between membrane proteins (MPs) and lipid bilayers are critical for many
cellular functions. In the Rosetta molecular modeling suite, the implicit membrane energy …

Membrane-protein design is an exciting and increasingly successful research area which
has led to landmarks including the design of stable and accurate membrane-integral …

After decades of progress in computational protein design, the design of proteins folding and
functioning in lipid membranes appears today as the next frontier. Some notable successes …

Transmembrane proteins (TMPs) are a class of essential proteins for biological and
therapeutic purposes. Despite an increasing number of structures, the gap with the number …

In silico validation of de novo designed proteins with deep learning (DL)-based structure
prediction algorithms has become a mainstream practice. However, formal evidence of the …

The voltage-gated potassium channel KCNQ1 (KV7. 1) assembles with the KCNE1
accessory protein to generate the slow delayed rectifier current, IKS, which is critical for …

Membrane proteins play critical physiological roles as receptors, channels, pumps, and
transporters. Despite their importance, however, low expression levels often hamper the …