Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …

The discovery of novel synthetic compounds with drug-like properties is an ongoing
challenge in medicinal chemistry. Natural products have inspired the synthesis of …

The increasing incidence of antibiotic resistance has forced the development of unique
antimicrobials with novel multitargeting mechanisms to combat infectious diseases caused …

Lung cancer is the most common malignancy and leads to around one-quarter of all cancer
deaths. Great advances have been achieved in the treatment of lung cancer with novel …

Unsatisfactory outcomes for relapsed/refractory lymphoma patients prompt continuing efforts
to develop new therapeutic strategies. Our previous studies on pyrrole-based anti …

With the soaring of bacterial infection and drug resistance, it is imperative to exploit new
efficient antibacterial agents. This work constructed a series of unique phenylhydrazone …

Main observation and conclusion The limit ability of traditional antibiotics to treat drug
resistant bacteria calls for new therapeutic alternatives. A class of unique sulfanilamide …

A series of 2-aminothiazole sulfanilamide oximes were developed as new membrane active
antibacterial agents to conquer the microbial infection. Benzoyl derivative 10c was …

This work did a new exploration towards aminothiazolquinolone oximes as potentially multi-
targeting antimicrobial agents. A class of novel hybrids of quinolone, aminothiazole …

The dreadful bacterial resistance to clinical drugs calls for the development of novel
antibacterials. This work developed a class of unique metronidazole-derived three …