SOX2 is a well-characterized pluripotent factor that is essential for stem cell self-renewal,
reprogramming, and homeostasis. The cellular levels of SOX2 are precisely regulated by a …

Sox family transcription factors are well-established regulators of cell fate decisions during
development. Accumulating evidence documents that they play additional roles in adult …

Sex determining region Y-box 2 (Sox2), a member of the SoxB1 transcription factor family, is
an important transcriptional regulator in pluripotent stem cells (PSCs). Together with octamer …

Research of the past view years expanded our understanding of the various physiological
functions the cell-fate determining transcription factor SOX2 exerts in ontogenesis …

Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …

Because nucleosomes are widely replaced by protamine in mature human sperm, the
epigenetic contributions of sperm chromatin to embryo development have been considered …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression and play an
important role in many developmental processes. We report here that expression of …

The pluripotency-associated transcription factor SOX2 is essential during mammalian
embryogenesis and later in life, but SOX2 expression can also be highly detrimental. Over …

Induced pluripotent stem (iPS) cells can be generated using retroviral vectors expressing
Oct4, Klf4, Sox2, and cMyc. Most prior studies have required multiple retroviral vectors for …