PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …

INTRODUCTION The complete sequence of animal genomes has had a transformative
impact on biological research. Whereas the genome sequence of an organism contains the …

Proliferating cells known as neoblasts include pluripotent stem cells (PSCs) that sustain
tissue homeostasis and regeneration of lost body parts in planarians. However, the lack of …

Pluripotent cells in the embryo can generate all cell types, but lineage-restricted cells are
generally thought to replenish adult tissues. Planarians are flatworms and regenerate from …

The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unanticipated
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …

In animals, small RNA molecules termed PIWI-interacting RNAs (piRNAs) silence
transposable elements (TEs), protecting the germline from genomic instability and mutation …

Abstract Small RNAs bound to Argonaute proteins recognize partially or fully complementary
nucleic acid targets in diverse gene-silencing processes,,,. A subgroup of the Argonaute …

The ability of animals to regenerate missing parts is a dramatic and poorly understood
aspect of biology. The sources of new cells for these regenerative phenomena have been …

Planarians are flatworms capable of regenerating any missing body region. This capacity is
mediated by neoblasts, a proliferative cell population that contains pluripotent stem cells …