New Approaches to the Prevention of Visceral Leishmaniasis: A Review of Recent Patents of Potential Candidates for a Chimeric Protein Vaccine
DS Oliveira, MF Zaldívar, AAM Gonçalves, LA Resende… - Vaccines, 2024 - mdpi.com
The development of prophylactic vaccines is important in preventing and controlling
diseases such as visceral leishmaniasis (VL), in addition to being an economic measure for …
diseases such as visceral leishmaniasis (VL), in addition to being an economic measure for …
Innovations in antifungal drug discovery among cell envelope synthesis enzymes through structural insights
Y Zhou, TB Reynolds - Journal of Fungi, 2024 - mdpi.com
Life-threatening systemic fungal infections occur in immunocompromised patients at an
alarming rate. Current antifungal therapies face challenges like drug resistance and patient …
alarming rate. Current antifungal therapies face challenges like drug resistance and patient …
Homology Modeling, de Novo Design of Ligands, and Molecular Docking Identify Potential Inhibitors of Leishmania donovani 24-Sterol Methyltransferase
The therapeutic challenges pertaining to leishmaniasis due to reported chemoresistance
and toxicity necessitate the need to explore novel pathways to identify plausible inhibitory …
and toxicity necessitate the need to explore novel pathways to identify plausible inhibitory …
Inhibiting Leishmania donovani Sterol Methyltransferase to Identify Lead Compounds Using Molecular Modelling
The recent outlook of leishmaniasis as a global public health concern coupled with the
reportage of resistance and lack of efficacy of most antileishmanial drugs calls for a …
reportage of resistance and lack of efficacy of most antileishmanial drugs calls for a …
[HTML][HTML] Targeting Leishmania donovani sterol methyltransferase for leads using pharmacophore modeling and computational molecular mechanics studies
The mortalities and morbidities of leishmaniasis are high and the disease is under reported
globally. The absence of vaccines coupled with chemotherapeutic challenges including …
globally. The absence of vaccines coupled with chemotherapeutic challenges including …
Dual RNA-Seq Analysis of Trichophyton rubrum and HaCat Keratinocyte Co-Culture Highlights Important Genes for Fungal-Host Interaction
MF Petrucelli, K Peronni, PR Sanches, TT Komoto… - Genes, 2018 - mdpi.com
The dermatophyte Trichophyton rubrum is the major fungal pathogen of skin, hair, and nails
that uses keratinized substrates as the primary nutrients during infection. Few strategies are …
that uses keratinized substrates as the primary nutrients during infection. Few strategies are …
Repurposing of FDA‐approved drugs as inhibitors of sterol C‐24 methyltransferase of Leishmania donovani to fight against leishmaniasis
Leishmaniasis is a vector‐borne disease caused by around 20 species of Leishmania. The
main clinical forms of leishmaniasis are cutaneous leishmaniasis (CL) and visceral …
main clinical forms of leishmaniasis are cutaneous leishmaniasis (CL) and visceral …
Subtractive genomics, molecular docking and molecular dynamics simulation revealed LpxC as a potential drug target against multi-drug resistant Klebsiella …
The emergence and dissemination of pan drug resistant clones of Klebsiella pneumoniae
are great threat to public health. In this regard new therapeutic targets must be highlighted to …
are great threat to public health. In this regard new therapeutic targets must be highlighted to …
Novel chemical scaffold as potential drug against Leishmania donovani: Integrated computational and experimental approaches
In this study, we have screened a large number of Food and Drug Administration‐approved
compounds for novel anti‐leishmanial molecules targeting the citrate synthase enzyme of …
compounds for novel anti‐leishmanial molecules targeting the citrate synthase enzyme of …
Sterol biosynthesis pathway as an alternative for the anti-protozoan parasite chemotherapy
S Teixeira de Macedo-Silva, W de Souza… - Current medicinal …, 2015 - benthamdirect.com
Sterols play an essential role in the physiology of eukaryotic cells; they play a pivotal role in
the normal structure and function of cell membranes and also act as precursors for the …
the normal structure and function of cell membranes and also act as precursors for the …