Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Neutrophils play a key role in defence against infection and in the activation and regulation
of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have …

Metastasis causes breast cancer-related mortality. Tumor-infiltrating neutrophils (TINs) inflict
immunosuppression and promote metastasis. Therapeutic debilitation of TINs may enhance …

Classically considered short-lived and purely defensive leukocytes, neutrophils are unique
in their fast and moldable response to stimulation. This plastic behavior may underlie …

The diverse leukocyte infiltrate in atherosclerotic mouse aortas was recently analyzed in 9
single-cell RNA sequencing and 2 mass cytometry studies. In a comprehensive meta …

Neutrophils have traditionally been viewed as bystanders or biomarkers of cardiovascular
disease. However, studies in the past decade have demonstrated the important functions of …

Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of
cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are …

APOE4 is the strongest genetic risk factor for Alzheimer's disease (AD), with increased odds
ratios in female carriers. Targeting amyloid plaques shows modest improvement in male non …

The metastatic process of colorectal cancer (CRC) is not fully understood and effective
therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal …

As one of the first defenders of innate immune response, neutrophils make a rapid and
robust response against infection or harmful agents. While traditionally regarded as suicidal …