Members of the protein superfamily of small guanosine triphosphatases, also known as
small GTPases, small G-proteins, or the Ras superfamily, are involved in nearly every aspect …

Microglia are crucial for maintaining brain health and neuron function. Here, we report that
microglia establish connections with neurons using tunneling nanotubes (TNTs) in both …

Programmed cell death and its specific form apoptosis play an important role during
development of multicellular organisms. They are crucial for morphogenesis and organ …

Programmed cell death is an integral component of Caenorhabditis elegans development.
Genetic and reverse genetic studies in C. elegans have led to the identification of many …

Ageing is a progressive deterioration in functional and structural well-being of the body,
accompanied with age-associated neurological disorders such as Parkinson's disease (PD) …

Patients with Parkinson's disease (PD) display non-motor symptoms arising prior to the
appearance of motor signs and before a clear diagnosis. Motor and non-motor symptoms …

Parkinson's disease is associated with intracellular α-synuclein accumulation and ventral
midbrain dopaminergic neuronal death in the Substantia Nigra of brain patients. The Rho …

Ubiquitination, a critical post-translational modification of proteins, refers to the covalent
attachment of ubiquitin to the substrate and is involved in various biological processes such …

Cytokinesis is driven by constriction of an actomyosin contractile ring that is controlled by
Rho-family small GTPases. Rho, activated by the guanine-nucleotide exchange factor ECT …

Aging is an unavoidable phenomenon, often afflicting structure and functionality of body,
marked with onset of age associated manifestations. Parkinson's disease (PD), the second …