The shortage of donor livers considered suitable for transplantation has driven the
development of novel methods for organ preservation and reconditioning. Machine …

Liver transplantation is currently the only curative therapy for patients with acute or chronic
liver failure. However, a dramatic gap between the number of available liver grafts and the …

The ability to preserve metabolically active livers ex vivo for 1 week or more could allow
repair of poor-quality livers that would otherwise be declined for transplantation. Current …

With the aim to explore innovative tools for organ preservation, especially in marginal
organs, we hereby describe a clinical trial of ex-vivo hypothermic oxygenated perfusion …

Oxygenated ex situ machine perfusion of donor livers is an alternative for static cold
preservation that can be performed at temperatures from 0° C to 37° C. Organ metabolism …

Mitochondria sense changes resulting from the ischemia and subsequent reperfusion of an
organ and mitochondrial reactive oxygen species (ROS) production initiates a series of …

The ever‐widening gap between organ supply and demand has resulted in an organ
shortage crisis that affects patients all over the world. For decades, static cold storage (SCS) …

To expand the donor pool of suitable organs for transplantation, there is an increased
interest in utilizing extended criteria donor grafts (ECD). Ex-situ machine perfusion has …

Definition Antipsychotics (APs) are psychotropic drugs that generally have a psycholeptic
effect, capable of reducing psychotic symptoms and psychomotor agitation. This class of …

Although short‐term machine perfusion (≤ 24 h) allows for resuscitation and viability
assessment of high‐risk donor livers, the donor organ shortage might be further remedied by …