There is growing evidence that genetic variation plays an important role in the determination
of individual susceptibility to complex disease traits. In contrast to coding sequence …

Transmission of HIV first results in an acute infection, followed by an apparently
asymptomatic period that averages ten years. In the absence of antiretroviral treatment, most …

The identification of chemokine receptors as necessary co-receptors for HIV entry into target
cells represented a breakthrough in the understanding of the pathogenesis of this viral …

Kawasaki disease (KD) is an enigmatic, self-limited vasculitis of childhood that is
complicated by development of coronary-artery aneurysms. The high incidence of KD in …

Just over a decade ago, the specific chemokine receptors CXCR4 and CCR5 were identified
as the essential coreceptors that function along with CD4 to enable human …

CCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as
promoter region that alter cell surface expression have been associated with disease …

Abstract Human Immunodeficiency Virus (HIV) infection dynamics is strongly influenced by
the host genetic background. NKG2C is an activating receptor expressed mainly on Natural …

The effects of the challenge dose and major histocompatibility complex (MHC) class IB
alleles were analyzed in 112 Mauritian cynomolgus monkeys vaccinated (n= 67) or not …

Infection with human immunodeficiency virus (HIV)-encoding defective nef variants may
contribute to a relatively benign course of disease in a minority of long-term nonprogressors …

Background Ethnic differences have the potential to confound associations between HIV-1
subtype and immunologic progression. We compared declines in CD4 cell counts during …