Approximately 20% of patients diagnosed with a phaeochromocytoma or paraganglioma
carry a germline mutation in one of the succinate dehydrogenase (SDHx) genes (SDHA …

Succinate is an important metabolite at the cross-road of several metabolic pathways, also
involved in the formation and elimination of reactive oxygen species. However, it is …

Succinate dehydrogenase (SDH)-deficient renal carcinoma has been accepted as a
provisional entity in the 2013 International Society of Urological Pathology Vancouver …

The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate
dehydrogenase (SDH; mitochondrial complex II), a mitochondrial enzyme involved in two …

Succinate dehydrogenase (or Electron Transport Chain Complex II) has been the subject of
a focused but significant renaissance. This complex, which has been the least studied of the …

Metabolism is the fundamental process for all cellular functions. For decades, there has
been growing evidence with regard to the relationship between metabolism and malignant …

The paraganglioma (PGL) syndromes types 1–5 are autosomal dominant disorders
characterized by familial predisposition to PGLs, phaeochromocytomas (PCs), renal cell …

Succinate dehydrogenase B (SDHB) and D (SDHD) subunit gene mutations predispose to
adrenal and extraadrenal pheochromocytomas, head and neck paragangliomas (HNPGL) …

Context: Germline mutations in SDHx genes cause hereditary paraganglioma. Objective:
The aim of the study was to assess the indications for succinate dehydrogenase (SDH) …

A genetic predisposition for paragangliomas and adrenal or extra‐adrenal
phaeochromocytomas was recognized years ago. Beside the well‐known syndromes …