Development of artemisinin resistance in malaria therapy
J Nass, T Efferth - Pharmacological Research, 2019 - Elsevier
Malaria affects 200 million people worldwide. Today, the most successful treatments are
artemisinin-based combination therapies (ACT). Resistance has already been described for …
artemisinin-based combination therapies (ACT). Resistance has already been described for …
[HTML][HTML] CRISPR/Cas advancements for genome editing, diagnosis, therapeutics, and vaccine development for Plasmodium parasites, and genetic engineering of …
L Nourani, AA Mehrizi, S Pirahmadi… - Infection, Genetics and …, 2023 - Elsevier
Malaria as vector-borne disease remains important health concern with over 200 million
cases globally. Novel antimalarial medicines and more effective vaccines must be …
cases globally. Novel antimalarial medicines and more effective vaccines must be …
Prevalence of Mutations in the Pfdhfr, Pfdhps, and Pfmdr1 Genes of Malarial Parasites Isolated from Symptomatic Patients in Dogondoutchi, Niger
I Issa, MM Lamine, V Hubert, A Ilagouma… - Tropical Medicine and …, 2022 - mdpi.com
The effectiveness of artemisinin-based combination therapies (ACTs) depends not only on
that of artemisinin but also on that of partner molecules. This study aims to evaluate the …
that of artemisinin but also on that of partner molecules. This study aims to evaluate the …
Assessment of copy number variation in genes related to drug resistance in Plasmodium vivax and Plasmodium falciparum isolates from the Brazilian Amazon and a …
GL Costa, LC Amaral, CJF Fontes, LH Carvalho… - Malaria journal, 2017 - Springer
Background Parasite resistance to anti-malarials represents a great obstacle for malaria
elimination. The majority of studies have investigated the association between single …
elimination. The majority of studies have investigated the association between single …
Increased sensitivity of malaria parasites to common antimalaria drugs after the introduction of artemether-lumefantrine: Implication of policy change and …
W Okore, C Ouma, RO Okoth, R Yeda, LO Ingasia… - PLOS …, 2024 - journals.plos.org
Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum multi-drug
resistance protein 1 (Pfmrp1) gene have previously been reported to confer resistance to …
resistance protein 1 (Pfmrp1) gene have previously been reported to confer resistance to …
Plasmodium falciparum Multidrug Resistance Proteins (pfMRPs)
JP Gil, C Fançony - Frontiers in Pharmacology, 2021 - frontiersin.org
The capacity of the lethal Plasmodium falciparum parasite to develop resistance against anti-
malarial drugs represents a central challenge in the global control and elimination of …
malarial drugs represents a central challenge in the global control and elimination of …
Four years' monitoring of in vitro sensitivity and candidate molecular markers of resistance of Plasmodium falciparum to artesunate-mefloquine combination in the …
P Phompradit, P Muhamad, R Wisedpanichkij… - Malaria journal, 2014 - Springer
Background The decline in efficacy of artesunate (AS) and mefloquine (MQ) is now the
major concern in areas along the Thai-Cambodian and Thai-Myanmar borders. Methods …
major concern in areas along the Thai-Cambodian and Thai-Myanmar borders. Methods …
A high-content phenotypic screen reveals the disruptive potency of quinacrine and 3′, 4′-dichlorobenzamil on the digestive vacuole of Plasmodium falciparum
YQ Lee, ASP Goh, JH Ch'ng, FH Nosten… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Plasmodium falciparum is the etiological agent of malignant malaria and has been shown to
exhibit features resembling programmed cell death. This is triggered upon treatment with …
exhibit features resembling programmed cell death. This is triggered upon treatment with …
Antiplasmodial cyclodecapeptides from tyrothricin share a target with chloroquine
ANN Leussa, M Rautenbach - Antibiotics, 2022 - mdpi.com
Previous research found that the six major cyclodecapeptides from the tyrothricin complex,
produced by Brevibacillus parabrevis, showed potent activity against chloroquine sensitive …
produced by Brevibacillus parabrevis, showed potent activity against chloroquine sensitive …
Examining Plasmodium falciparum and P. vivax clearance subsequent to antimalarial drug treatment in the Myanmar-China border area based on quantitative real …
E Lo, J Nguyen, W Oo, E Hemming-Schroeder… - BMC infectious …, 2016 - Springer
Background Recent emergence of artemisinin-resistant P. falciparum has posed a serious
hindrance to the elimination of malaria in the Greater Mekong Subregion. Parasite clearance …
hindrance to the elimination of malaria in the Greater Mekong Subregion. Parasite clearance …