Non-alcoholic fatty liver disease (NAFLD) includes a range of hepatic manifestations,
starting with liver steatosis and potentially evolving towards non-alcoholic steatohepatitis …

The metabolic stress occurring in the tumor microenvironment (TME) hampers T cell anti-
tumor immunity by disturbing T cell metabolic and epigenetic programs. Recent studies are …

Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease
related to obesity, and causes liver disease and cancer,. The accumulation of metabolites …

Tissue resident memory CD8+ T (TRM) cells offer rapid and long-term protection at sites of
reinfection. Tumour-infiltrating lymphocytes with characteristics of TRM cells maintain …

Throughout life, T cells coordinate multiple aspects of adaptive immunity, including
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is …

Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease that can
progress to liver fibrosis. Recent clinical advance suggests a reversibility of liver fibrosis, but …

The liver connects the intestinal portal vasculature with the general circulation, using a
diverse array of immune cells to protect from pathogens that translocate from the gut. In liver …

CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …

The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …