Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast
majority of the social OA burden is related to hips and knees. The prevalence of knee OA …

Objective To systematically review the literature on the relationship between markers of
inflammation and pain in patients with knee osteoarthritis (OA). Methods We searched …

Synovial joints are complex structures that enable normal locomotion. Following injury, they
undergo a series of changes, including a prevalent inflammatory response. This increases …

Objective Obesity was once considered a risk factor for knee osteoarthritis (OA) primarily for
biomechanical reasons. Here we provide an additional perspective by discussing how …

Osteoarthritis (OA) is a chronic, progressive, multifactorial disease resulting in a progressive
loss of articular cartilage structure and function that is most common in middle-aged and …

Osteoarthritis (OA) is a chronic and debilitating disease of the knee joint. OA of the knee is
initiated by physical damage and accumulated oxidative stress, followed by an exaggerated …

Osteoarthritis (OA) is a multifactorial joint disease with pathological changes that affect
whole joint tissue. Obesity is acknowledged as the most influential risk factor for both the …

Objective We evaluated the association between monocyte chemotactic protein-1 (MCP-1)
and osteoarthritis. Methods We searched PubMed, Cochrane Library, Embase, Web of …

Most advanced knee osteoarthritis (OA) patients experience chronic pain resistant to
cyclooxygenase (COX) inhibitors. However, the cells and molecules involved in this …

Pain is an unpleasant sensation associated with injury, inflammation, and infection. It has
been demonstrated that communication between immune cells and neurons plays a vital …