Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Aldehyde dehydrogenase (ALDH) is an enzyme that participates in important cellular
mechanisms as aldehyde detoxification and retinoic acid synthesis; moreover, ALDH activity …

Acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid
leukemia (AML), characterized by the t (15; 17)-associated PML-RARA fusion, has been …

Purpose: To examine the role of cancer stem cells (CSC) in mediating metastasis in
inflammatory breast cancer (IBC) and the association of these cells with patient outcome in …

Tanshinones are a class of abietane diterpene compound isolated from Salvia miltiorrhiza
(Danshen or Tanshen in Chinese), a well-known herb in Traditional Chinese Medicine …

Despite advances in treatment, cancer remains the 2nd most common cause of death in the
United States. Poor cure rates may result from the ability of cancer to recur and spread after …

Epigenetic reprogramming plays a pivotal role during embryogenesis, including both
covalent and non-covalent modifications to chromatin. In this study, we investigated the role …

Chemotherapy in cancer patients is still not satisfactory because of drug resistance. The
main mechanism of drug resistance results from the ability of cancer cells to actively expel …

Acute myeloid leukemia is characterized by arrested differentiation, and agents that
overcome this block are therapeutically useful, as shown by the efficacy of all-trans retinoic …

Early in the age of modern medicine the consequences of vitamin A deficiency drew
attention to the fundamental link between retinoid-dependent homeostatic regulation and …