Mimicking biofilm formation and development: Recent progress in in vitro and in vivo biofilm models

I Guzmán-Soto, C McTiernan, M Gonzalez-Gomez… - Iscience, 2021 - cell.com
Biofilm formation in living organisms is associated to tissue and implant infections, and it has
also been linked to the contribution of antibiotic resistance. Thus, understanding biofilm …

Mechanomicrobiology: how bacteria sense and respond to forces

YF Dufrêne, A Persat - Nature Reviews Microbiology, 2020 - nature.com
Microorganisms have evolved to thrive in virtually any terrestrial and marine environment,
exposing them to various mechanical cues mainly generated by fluid flow and pressure as …

Spatial transcriptomics of planktonic and sessile bacterial populations at single-cell resolution

D Dar, N Dar, L Cai, DK Newman - Science, 2021 - science.org
INTRODUCTION Microbial populations display heterogeneous gene expression profiles that
result in phenotypic differences between individual bacteria. This diversity can allow …

Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa

LZ Ma, D Wang, Y Liu, Z Zhang… - Annual review of …, 2022 - annualreviews.org
Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the
natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms …

How bacteria recognise and respond to surface contact

TEP Kimkes, M Heinemann - FEMS microbiology reviews, 2020 - academic.oup.com
Bacterial biofilms can cause medical problems and issues in technical systems. While a
large body of knowledge exists on the phenotypes of planktonic and of sessile cells in …

Pseudomonas aeruginosa breaches respiratory epithelia through goblet cell invasion in a microtissue model

AL Swart, BJ Laventie, R Sütterlin, T Junne… - Nature …, 2024 - nature.com
Pseudomonas aeruginosa, a leading cause of severe hospital-acquired pneumonia, causes
infections with up to 50% mortality rates in mechanically ventilated patients. Despite some …

Wrapped up: the motility of polarly flagellated bacteria

KM Thormann, C Beta, MJ Kühn - Annual Review of …, 2022 - annualreviews.org
A huge number of bacterial species are motile by flagella, which allow them to actively move
toward favorable environments and away from hazardous areas and to conquer new …

Multiple roles of c-di-GMP signaling in bacterial pathogenesis

M Valentini, A Filloux - Annual review of microbiology, 2019 - annualreviews.org
The intracellular signaling molecule cyclic di-GMP (c-di-GMP) regulates the lifestyle of
bacteria and controls many key functions and mechanisms. In the case of bacterial …

A genetic switch controls Pseudomonas aeruginosa surface colonization

C Manner, R Dias Teixeira, D Saha… - Nature …, 2023 - nature.com
Efficient colonization of mucosal surfaces is essential for opportunistic pathogens like
Pseudomonas aeruginosa, but how bacteria collectively and individually adapt to optimize …

Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations

CR Armbruster, CK Lee, J Parker-Gilham, J de Anda… - Elife, 2019 - elifesciences.org
The second messenger signaling molecule cyclic diguanylate monophosphate (c-di-GMP)
drives the transition between planktonic and biofilm growth in many bacterial species …