Summary The sphingosine 1-phosphate (S1P) signalling pathways have important and
diverse functions. S1P receptors (S1PRs) have been proposed as a therapeutic target for …

Sphingolipids, including the two central bioactive lipids ceramide and sphingosine-1-
phosphate (S1P), have opposing roles in regulating cancer cell death and survival …

Sphingolipids are a specialized group of lipids essential to the composition of the plasma
membrane of many cell types; however, they are primarily localized within the nervous …

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

The Hippo pathway controls organ size in diverse species, whereas pathway deregulation
can induce tumours in model organisms and occurs in a broad range of human carcinomas …

Membrane sphingolipids are metabolized to sphingosine-1-phosphate (S1P), a bioactive
lipid mediator that regulates many processes in vertebrate development, physiology, and …

The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …

Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …

Metastasis is the leading cause of death for cancer patients. This multi-stage process
requires tumour cells to survive in the circulation, extravasate at distant sites, then …

The potent pleiotropic lipid mediator sphingosine-1-phosphate (S1P) participates in
numerous cellular processes, including angiogenesis and cell survival, proliferation, and …