Obesity is a chronic and progressive process affecting whole-body energy balance and is
associated with comorbidity development. In addition to increased fat mass, obesity induces …

Obesity is causally linked with the development of cardiovascular disorders. Accumulating
evidence indicates that cardiovascular disease is the collateral damage of obesity-driven …

Obesity originates from an imbalance between caloric intake and energy expenditure that
promotes adipose tissue expansion, which is necessary to buffer nutrient excess. Patients …

The extracellular matrix (ECM) is a network of different proteins and proteoglycans that
controls differentiation, migration, repair, survival, and development, and it seems that its …

Obesity is characterized by a state of chronic, low-grade inflammation. However, excessive
fatty acid release may worsen adipose tissue inflammation and contributes to insulin …

Hypoxia can be defined as a relative deficiency in the amount of oxygen reaching the
tissues. Hypoxia-inducible factors (HIFs) are critical regulators of the mammalian response …

During the last decades, research on adipose tissues has spread in parallel with the
extension of obesity. Several observations converged on the idea that adipose tissues are …

Metabolic diseases such as obesity and type 2 diabetes are marked by insulin resistance,.
Cells within the arcuate nucleus of the hypothalamus (ARC), which are crucial for regulating …

Obesity-induced white adipose tissue (WAT) fibrosis is believed to accelerate WAT
dysfunction. However, the cellular origin of WAT fibrosis remains unclear. Here, we show …

At the simplest level, obesity is the manifestation of an imbalance between caloric intake and
expenditure; however, the pathophysiological mechanisms that govern the development of …