Functional and structural inter-relationships of RNA and proteins in the execution and
control of biological processes such as RNA processing, RNA splicing, and translation are …

The sequencing of the human genome and the elucidation of many molecular pathways that
are important in disease have provided unprecedented opportunities for the development of …

Quantitative measurements of biomolecule associations are central to biological
understanding and are needed to build and test predictive and mechanistic models. Given …

The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired
stems and a core of highly conserved, non-complementary nucleotides essential for …

We previously reported the in vitro selection of a general-purpose RNA-cleaving DNA
enzyme that exhibits a catalytic efficiency (k cat/KM) exceeding that of any other known …

Background: Previously we demonstrated that DNA can act as an enzyme in the Pb 2t-
dependent cleavage of an RNA phosphoester. This is a facile reaction, with an uncatalyzed …

RNA performs important cellular functions in contemporary life forms. Its ability to act both as
a catalyst and a storage mechanism for genetic information is also an important part of the …

▪ Abstract The past few years have seen exciting advances in understanding the structure
and function of catalytic RNA. Crystal structures of several ribozymes have provided detailed …

Divalent cations, like magnesium, are crucial for the structural integrity and biological activity
of RNA. In this article, we present a picture of how magnesium stabilizes a particular folded …

The hammerhead ribozyme is one of the smallest ribozymes known and catalyses the site‐
specific hydrolysis of a phosphodiester bond. This small ribozyme is of interest for two …