Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …

Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory
diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on …

Immune-checkpoint blockade (ICB) promotes antitumor immune responses and can result in
durable patient benefit. However, response rates in breast cancer patients remain modest …

Intratumour heterogeneity (ITH) is a hallmark of cancer that drives tumour evolution and
disease progression. Technological and computational advances have enabled us to …

Wound healing is a dynamic and highly regulated process that can be separated into three
overlapping and interdependent phases: inflammation, proliferation, and remodelling. This …

Simple Summary The tumor microenvironment plays an important role in determining the
biological behavior of several of the more aggressive malignancies. Among the various cell …

Abstract Cancer-Associated Fibroblasts (CAFs) represent the most prominent component of
the tumor microenvironment (TME). Recent studies demonstrated that CAF are …

Cancer-associated fibroblasts (CAFs) are heterogeneous and ubiquitous stromal cells within
the tumor microenvironment (TME). Numerous CAF types have been described, typically …

Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …

T cell-based immunotherapies have exhibited promising outcomes in tumor control;
however, their efficacy is limited in immune-excluded tumors. Cancer-associated fibroblasts …