Neurotoxic effects of organophosphorus pesticides and possible association with neurodegenerative diseases in man: A review

M Jokanović - Toxicology, 2018 - Elsevier
In this article the neurotoxic disorders appearing in patients exposed to organophosphorus
pesticides and known mechanisms involved are reviewed. Organophosphorus compounds …

Multiple neurological effects associated with exposure to organophosphorus pesticides in man

M Jokanović, P Oleksak, K Kuca - Toxicology, 2023 - Elsevier
This article reviews available data regarding the possible association of organophosphorus
(OP) pesticides with neurological disorders such as dementia, attention deficit hyperactivity …

Visible-light-induced [1+ 5] annulation of phosphoryl diazomethylarenes and pyridinium 1, 4-zwitterionic thiolates

S Sun, Y Wei, J Xu - Organic Letters, 2022 - ACS Publications
Visible-light-induced [1+ 5] annulation of phosphoryl diazomethylarenes and pyridinium 1, 4-
zwitterionic thiolates generates various trifunctionalized dialkyl 1-phosphoryl-1, 9a …

SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides

L Gorecki, J Korabecny, K Musilek, D Malinak… - Archives of …, 2016 - Springer
Irreversible inhibition of acetylcholinesterase (AChE) by organophosphates leads to many
failures in living organism and ultimately in death. Organophosphorus compounds …

Strategies for enhanced bioavailability of oxime reactivators in the central nervous system

E Prchalova, Z Kohoutova, K Knittelova, D Malinak… - Archives of …, 2023 - Springer
Oxime reactivators of acetylcholinesterase are commonly used to treat highly toxic
organophosphate poisoning. They are effective nucleophiles that can restore the catalytic …

Antidotes in Clinical Toxicology—Critical Review

D Kobylarz, M Noga, A Frydrych, J Milan, A Morawiec… - Toxics, 2023 - mdpi.com
Poisoning and overdose are very important aspects in medicine and toxicology. Chemical
weapons pose a threat to civilians, and emergency medicine principles must be followed …

Computational enzymology and organophosphorus degrading enzymes: promising approaches toward remediation technologies of warfare agents and pesticides

T C. Ramalho, A A. de Castro, D R. Silva… - Current Medicinal …, 2016 - benthamdirect.com
The re-emergence of chemical weapons as a global threat in hands of terrorist groups,
together with an increasing number of pesticides intoxications and environmental …

Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes

V Jaćević, J Dumanović, J Grujić-Milanović… - Chemico-biological …, 2023 - Elsevier
Oxidative stress status and morphological injuries in the brain of Wistar rats induced by
repeated application of selected acetylcholinesterase reactivators–asoxime, obidoxime …

Therapeutic potential of multifunctional derivatives of cholinesterase inhibitors

M Przybyłowska, K Dzierzbicka… - Current …, 2021 - benthamdirect.com
The aim of this work is to review tacrine analogues from the last three years, which were not
included in the latest review work, donepezil and galantamine hybrids from 2015 and …

Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006–2016)

L Gorecki, J Korabecny, K Musilek… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: organophosphorus compounds act as irreversible inhibitors of the vital enzyme
acetylcholinesterase (AChE). this leads in the accumulation of acetylcholine (ACh) leading …