Adverse effects of triclosan exposure on health and potential molecular mechanisms

X Chen, L Mou, J Qu, L Wu, C Liu - Science of The Total Environment, 2023 - Elsevier
With the COVID-19 pandemic, the use of disinfectants has grown significantly around the
world. Triclosan (TCS), namely 5-chloro-2-(2, 4-dichlorophenoxy) phenol or 2, 4, 4 …

Triclosan: A small molecule with controversial roles

MS Sinicropi, D Iacopetta, J Ceramella, A Catalano… - Antibiotics, 2022 - mdpi.com
Triclosan (TCS), a broad-spectrum antimicrobial agent, has been widely used in personal
care products, medical products, plastic cutting boards, and food storage containers …

Taurocholic acid and glycocholic acid inhibit inflammation and activate farnesoid X receptor expression in LPS-stimulated zebrafish and macrophages

X Ge, S Huang, C Ren, L Zhao - Molecules, 2023 - mdpi.com
A hyperactive immune response can be observed in patients with bacterial or viral infection,
which may lead to the overproduction of proinflammatory cytokines, or “cytokine storm”, and …

Differential immunotoxicity effects of triclosan and triclocarban on larval zebrafish based on RNA-Seq and bioinformatics analysis

X Li, W Wang, X Wang, H Wang - Aquatic Toxicology, 2023 - Elsevier
Herein, we demonstrated that sublethal-dose exposure to triclosan (TCS) and triclocarban
(TCC) triggered larval zebrafish immunotoxicity. Acute exposure to TCS induced significant …

Effects of triclosan exposure on stem cells from human exfoliated deciduous teeth (SHED) fate

S Deng, C Li, J Chen, Z Cui, T Lei, H Yang… - Science of The Total …, 2023 - Elsevier
Triclosan (TCS), a widely used broad-spectrum antibacterial agent and preservative, is
commonly found in products and environments. Widespread human exposure to TCS has …

Acute/chronic triclosan exposure induces downregulation of m6A-RNA methylation modification via mettl3 suppression and elicits developmental and immune toxicity …

Q Qian, Q Pu, X Li, XC Liu, A Ni, X Han, Z Wang… - Chemosphere, 2024 - Elsevier
Triclosan (TCS), a prevalent contaminant in aquatic ecosystems, has been identified as a
potential threat to both aquatic biota and human health. Despite its widespread presence …

Immunotoxicity and transcriptome analysis of zebrafish embryos exposure to Nitazoxanide

W Lu, F Yang, Y Meng, J An, B Hu, S Jian… - Fish & Shellfish …, 2023 - Elsevier
Nitazoxanide (NTZ) is a broad-spectrum immunomodulatory drug, and little information is
about the immunotoxicity of aquatic organisms induced by NTZ. In the present study …

Frontier of toxicology studies in zebrafish model

X Shao, D Xiao, Z Yang, L Jiang, Y Li… - Journal of Applied …, 2024 - Wiley Online Library
Based on the 87 original publications only from quartiles 1 and 2 of Journal Citation Report
(JCR) collected by the major academic databases (Science Direct, Web of Science …

Triclosan reprograms immunometabolism and activates the inflammasome in human macrophages

P Yuan, F Shen, J Zhang, S Ouyang… - Environmental …, 2022 - ACS Publications
To gather enough energy to respond to harmful stimuli, most immune cells quickly shift their
metabolic profile. This process of immunometabolism plays a critical role in the regulation of …

Mechanism-based understanding of the potential cellular targets of triclosan in zebrafish larvae

F Wang, F Liu - Environmental Toxicology and Pharmacology, 2023 - Elsevier
Triclosan (TCS) has become widely distributed due to its widespread use. In this study, we
investigated the mechanisms of TCS's potential effects on cellular targets in zebrafish (Danio …