Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is
characterised by a variable clinical course–from symptomless cases to severe chronic …

Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both
rural and urban areas. CD was first described over a century ago, but only two drugs are …

Trypomastigote forms of Trypanosoma cruzi, the causative agent of Chagas Disease, shed
extracellular vesicles (EVs) enriched with glycoproteins of the gp85/trans-sialidase (TS) …

Introduction• Chagas' disease• Chemotherapy• Immune response in experimental T. cruzi
infection• Immune response in human beings infected with T. cruzi• Immune response in the …

Chronic Chagas cardiomyopathy (CCC) is the most frequent and severe form of Chagas
disease, a neglected tropical illness caused by the protozoan Trypanosoma cruzi, and the …

The protozoan Trypanosoma cruzi triggers an inflammatory process in mammalian heart
causing events such as fibrosis, changes in the architecture and functionality in this organ …

Background Adults with chronic Trypanosoma cruzi exhibit a poorly functional T cell
compartment, characterized by monofunctional (IFN-γ-only secreting) parasite-specific T …

Background: In contrast to adults, Trypanosoma cruzi-infected children have more broadly
functional Trypanosoma cruzi-specific T cells, and the total T-cell compartment exhibits …

There is a general consensus that during chronic Trypanosoma cruzi infection, the host
immune system induces complex processes to ensure the control of parasite growth while …

Trypanosoma cruzi infection may be caused by different strains with distinct discrete typing
units (DTUs) that can result in variable clinical forms of chronic Chagas disease. The present …