Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological
effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained …

Calcific aortic valve stenosis (CAVS), the most common heart valve disease, is characterized
by the slow progressive fibro-calcific remodeling of the valve leaflets, leading to progressive …

Arterial calcification is an important hallmark of cardiovascular disease and shares many
similarities with skeletal mineralization. The bone‐specific protein osteocalcin (OCN) is an …

Arterial medial calcification (AMC) is the deposition of calcium phosphate mineral, often as
hydroxyapatite, in the medial layer of the arteries. AMC shares some similarities to skeletal …

A series of clinical trials have confirmed the correlation between vascular calcification (VC)
and cardiovascular events and mortality. However, current treatments have little effects on …

Vascular calcification resulting from hyperphosphatemia is a major determinant of mortality
in chronic kidney disease (CKD). Vascular calcification is driven by aldosterone-sensitive …

Aldosterone is the most known mineralocorticoid hormone synthesized by the adrenal
cortex. The genomic pathway displayed by aldosterone is attributed to the mineralocorticoid …

Arterial calcification is an important characteristic of cardiovascular disease. It has key
parallels with skeletal mineralization; however, the underlying cellular mechanisms …

Corticosteroids are secreted by the adrenal glands and control the functions of adipose
tissue via the activation of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) …

Cushing's syndrome (CS) is associated with multisystemic complications; the hematological
system is not spared. Alteration in hemostatic parameters and in vivo endothelial dysfunction …