The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy
critical to neuronal function while simultaneously excluding neurotoxic substances from the …

The blood–brain barrier (BBB) is a highly regulated physical and functional boundary that
tightly controls the transport of materials between the blood and the brain. There is an …

Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in
the brain of Alzheimer's disease patients. Toxic proteases from the bacterium called …

Introduction Neutrophil accumulation is a well-established feature of Alzheimer's disease
(AD) and has been linked to cognitive impairment by modulating disease-relevant …

The incidence of Alzheimer's disease (AD), which is characterized by progressive cognitive
decline that correlates with the spread of tau protein aggregation in the cortical mantle, is …

Platelet-derived growth factor-BB (PDGF-BB): PDGF receptor-β (PDGFRβ) signalling in
brain pericytes is critical to the development, maintenance and function of a healthy blood …

Background Pericytes and endothelial cells are critical cellular components of the blood-
brain barrier (BBB) and play an important role in neuroinflammation. To date, the majority of …

Traditionally regarded to coordinate movement, the cerebellum also exerts non-motor
functions including the regulation of cognitive and behavioral processing, suggesting a …

Alzheimer-type dementia (AD) is a neurodegenerative disorder and the most common form
of dementia. Patients typically present with neuro-and systemic inflammation and iron …

Elevated pulse pressure can cause blood-brain barrier dysfunction and subsequent adverse
neurological changes that may drive or contribute to the development of dementia with age …