Fritillaria cirrhosa D. Don and F. thunbergii Miq. belong to the genus Fritillaria within the
Liliaceae family. They are used in traditional Chinese medicines that are often administered …

Isosteroidal alkaloids are kinds of alkaloids with unique structures and remarkable activities.
These compounds have important pharmacological activities, such as analgesic …

Objective This study aimed to explore the specific molecular mechanism of the therapeutic
effect of quercetin in knee osteoarthritis (KOA). Methods The KOA rat model was constructed …

Background This study aimed to investigate functions of GLP-1R agonist by liraglutide
(LIRA) and revealing the mechanism related to AGEs/RAGE in chondrocytes. Methods To …

Fritillaria naturally grows in the temperate region of Northern Hemisphere and mainly
distributes in Central Asia, Mediterranean region, and North America. The dried bulbs from a …

Osteoarthritis (OA) is one of the most chronic degenerative arthritic diseases, which
gradually results in chondrocyte changes, articular cartilage degeneration, subchondral …

Neuropathic pain is a complex and debilitating condition that affects millions of people
worldwide. Unlike acute pain, which is short-term and starts suddenly in response to an …

Background and purpose Peimine (PM), a main isosterol alkaloid component isolated from
the bulbs of traditional Chinese herb Fritillaria cirrhosa D. Don, has been demonstrated to …

The increasing use of anticancer drugs has led to the emergence of environmental
contaminants such as bleomycin (BLM), which poses significant threats to both aquatic …

Fritillariae thunbergii bulbus has been widely used to treat symptoms of coughs and airway
congestion in the chest due to pathological colds and damp phlegm in traditional Chinese …